Copure SPE (HLB family)
Biocomma Copure HLB: PS/DVB copolymer, pH 0–14, 500–750 m²/g, 200–400 Å, cartridges from 30 mg/1 mL to 500 mg/12 mL.
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Copure® HLB Hydrophilic-Lipophilic Balanced SPE Cartridges
Universal polymeric SPE cartridges balancing hydrophilic and hydrophobic retention, with 3-10 times the capacity of C18 silica, for acidic, neutral and basic analytes in complex matrices.
Key specifications
- Matrix
- PS/DVB copolymer (divinylbenzene and N-vinylpyrrolidone)
- Coefficient of variation
- <5 %
- Specific surface area
- 500-750 m²/g
- Particle size
- 20-60 µm
- Configured to your application by our specialists
- Installed and commissioned on site
- Training and after-sales support across Jordan, the GCC and MENA
Copure® HLB Hydrophilic-Lipophilic Balanced SPE Cartridges
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Product overview
Copure® HLB cartridges use a sorbent made by a special copolymerization technique, with a defined ratio of hydrophilic and hydrophobic groups. The hydrophobic divinylbenzene structure retains non-polar compounds, while the hydrophilic N-vinylpyrrolidone structure retains polar compounds. The sorbent wets well in water, and the hydrophilic-lipophilic balance can be adjusted through the aqueous phase to reach the desired selectivity.
HLB gives good recovery of acidic, neutral and basic compounds from non-polar to moderately polar, and is particularly suitable for complex matrices such as blood, urine and food. Its adsorption capacity and sample load are 3-10 times higher than C18 bonded silica, and it withstands pH 1-14 and most solvents.
Applications include drugs and illegal substances in blood (antidepressants, heroin), antibiotics, catecholamines and microcystins in animal-derived foods, and tetracyclines, quinolones, pesticides and mycotoxins in dairy products. Application notes cover doxycycline residues in eggs and multi-residue veterinary drugs in meat by LC-MS/MS.
Specifications
Technical specifications
13 parameters
Sorbent
- Matrix
- PS/DVB copolymer (divinylbenzene and N-vinylpyrrolidone)
- Coefficient of variation
- <5 %
- Specific surface area
- 500-750 m²/g
- Particle size
- 20-60 µm
- Pore size
- 200-400 Å
- Capacity vs C18 bonded silica
- 3-10 times higher
- pH tolerance
- 1-14
Ordering
- Catalog numbers (standard)
- COHLB130, COHLB360, COHLB3200, COHLB6150, COHLB6200, COHLB6500, COHLB12500
- Cartridge formats (standard)
- 30 mg/1 mL (100 pcs/box); 60 mg/3 mL (50 pcs/box); 200 mg/3 mL (50 pcs/box); 150 mg/6 mL (30 pcs/box); 200 mg/6 mL (30pcs/box); 500 mg/6 mL (30 pcs/box); 500 mg/12 mL (20 pcs/box)
- Equivalent to (per Biocomma)
- Waters Oasis HLB
Variants
- Variant COHLB360-9345
- 60 mg/3 mL, 50 pcs/box; particle size ≤30 µm; specific surface area 500-750 m²/g; pore size 200-400 Å; working pH 0-14
- Variant COHLB360C16
- 60 mg/3 mL, 50 pcs/box; particle size 20-60 µm; surface area 500-750 m²/g; pore size 80 Å; reversed-phase; polypropylene tube
- Variant COHLB6500C16
- 500 mg/6 mL, 30 pcs/box; particle size 60 µm; surface area 500-750 m²/g; pore size 80 Å; polypropylene tube
Features
Key features
- 01
Universal sorbent
Wide application range across acidic, neutral and basic compounds.
- 02
High water wettability
Resistant to solvent drying and not easily penetrated.
- 03
High recovery and reproducibility
Coefficient of variation below 5%.
- 04
3-10 times C18 capacity
Adsorption capacity and sample load far higher than C18 bonded silica.
- 05
Wide pH and solvent tolerance
Withstands pH 1-14 and most solvents.
- 06
Food and clinical applications
Drugs in blood, antibiotic residues in animal-derived foods, tetracyclines and quinolones in dairy.
From order to operation
We stay with the instrument after it arrives
Al-Shaker specifies the configuration, documents the system, and supports it across Jordan, the GCC, and MENA.
- 01
Consult
- 02
Plan
- 03
Supply
- 04
Install
- 05
Train
- 06
Support
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Talk to the technical team
Tell us the application. We will specify the system.
Share the workflow, capacity, and compliance constraints. We respond with a recommended configuration, not a generic catalogue list.