
Sykam Analytical HPLC Systems
Modular S 500 and S 600 HPLC for micro, analytical, and semi-preparative work, in stainless steel or bio-inert PEEK.
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Equipment guide
HPLC separates compounds dissolved in a liquid by pumping them through a packed column, then detects them as they elute. Match the pump pressure, detector and column format to your method, and decide early between analytical, preparative and ion-chromatography configurations.

Modular S 500 and S 600 HPLC for micro, analytical, and semi-preparative work, in stainless steel or bio-inert PEEK.
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S 700 preparative HPLC from isocratic to quaternary gradient, with flow rates up to 1000 ml/min and pressures up to 400 bar.
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Biocomma CommaSil fully porous silica HPLC: 3 / 3.5 / 5 μm particles, 2.1 / 3.0 / 4.6 mm IDs, lengths 30–250 mm.
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Modular and integrated ion chromatographs for anions, cations, transition metals, organic acids, and amines.
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Dedicated S 433 and S 633 analyzers with ready-to-use chemistry and columns for physiological fluids and food/feed hydrolysates.
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Manual and motorized switching valves for analytical and preparative HPLC flow paths.
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Bio-inert empty preparative HPLC columns in PEEK, with optional axial compression and pressure ratings up to 250 bar.
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Clarity chromatography data software for analytical HPLC, and PrepCon control software for preparative LC/HPLC.
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Sykam S 6010 / S 6110 analytical injection valve for HPLC; stainless steel and biocompatible PEEK versions, up to 400 bar.
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Sykam S 6011 / S 6111 preparative injection valve for HPLC; stainless steel and biocompatible PEEK versions, up to 250 bar.
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Stainless steel 2-position HPLC valve from Sykam with a needle injection port on the top side, designed for use in autosamplers.
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Sykam S 6020 / S 6120 needle injection valve for HPLC; stainless steel and biocompatible PEEK versions, up to 400 bar.
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Standard 400 bar systems cover most methods; 600 bar and above suit small-particle columns and fast separations.
UV/DAD for most pharma and food work, RI for sugars and polymers, fluorescence for trace analytes, conductivity for ion chromatography.
Analytical systems identify and quantify; preparative systems isolate material, with larger columns, higher flow and fraction collection.
Column chemistry is method-specific. Securing a reliable local source for columns, filters, vials and fittings protects uptime.
Choose chromatography software that supports audit trails and 21 CFR Part 11 workflows if your laboratory is regulated.
Each range is supplied with installation, operator training and local service.
Both pump a liquid through a column. HPLC separates by polarity or size on silica-based columns; ion chromatography separates charged species on ion-exchange columns with a conductivity detector, typically for anions and cations in water.
It depends on the matrix, mobile phase and pH, but a falling plate count, rising backpressure or peak tailing signals replacement. Guard columns and sample filtration extend column life.
Yes. The catalog includes HPLC columns, pumps, ovens, microsyringes and accessories alongside complete Sykam systems, with support from the Al-Shaker technical team.
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Share the workflow, capacity, and compliance constraints. We respond with a recommended configuration, not a generic catalogue list.